TMOD-09. TUMOR ASSOCIATED MACROPHAGE DYNAMICS IN PEDIATRIC HIGH-GRADE GLIOMAS
نویسندگان
چکیده
منابع مشابه
High-throughput microRNA profiling of pediatric high-grade gliomas
BACKGROUND High-grade gliomas (HGGs) account for 15% of all pediatric brain tumors and are a leading cause of cancer-related mortality and morbidity. Pediatric HGGs (pHGGs) are histologically indistinguishable from their counterpart in adulthood. However, recent investigations indicate that differences occur at the molecular level, thus suggesting that the molecular path to gliomagenesis in chi...
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The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%. Diffuse intrinsic pontine glioma (DIPG) comprise a subset of HGG that arise in the brainstem almost exclusively in children. Genome-wide analyses of copy number imbalances previously showed that platelet-derived growth factor receptor α (PDGFRA) is the most frequent target of f...
متن کاملCharacterizing temporal genomic heterogeneity in pediatric high-grade gliomas
Pediatric high-grade gliomas (pHGGs) are aggressive neoplasms representing approximately 20% of brain tumors in children. Current therapies offer limited disease control, and patients have a poor prognosis. Empiric use of targeted therapy, especially at progression, is increasingly practiced despite a paucity of data regarding temporal and therapy-driven genomic evolution in pHGGs. To study the...
متن کاملTargeting Wee1 for the treatment of pediatric high-grade gliomas.
BACKGROUND We investigated the efficacy of the Wee1 inhibitor MK-1775 in combination with radiation for the treatment of pediatric high-grade gliomas (HGGs), including diffuse intrinsic pontine gliomas (DIPGs). METHODS Gene expression analysis was performed for 38 primary pediatric gliomas (3 grade I, 10 grade II, 11 grade III, 14 grade IV) and 8 normal brain samples using the Agilent 4 × 44 ...
متن کاملcomparative proteomic analysis of tumor mesenchymal-like cells derived from high grade vs. low grade gliomas
objective: gliomas are the most common primary brain tumors, and have been ranked as the fourth leading cause of cancer death. tumor mesenchymal-like stem cells (tmscs) contribute to the aggressive behavior of glial tumors by providing a favorable microenvironment for the malignant cells. the aims of our study were to identify differential proteome of tmscs derived from low vs. high grade gliom...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2019
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/noz036.247